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Looking for the simulation web site  evolutiongenetics.georgetown.edu? See below.

Population Genetics, 2nd Edition
Published by Wiley-Blackwell


Population Genetics 2E is a survey textbook designed for advanced undergraduate and graduate students. Newly revised and updated. 

The book is accompanied by a web site with instructions, links and downloads for problems and Interact Boxes. There is also web page with instructor resources (registration required).

​For more information or to purchase the book go to https://www.wiley.com/en-us/Population+Genetics,+2nd+Edition-p-9781118436943​
​

Contents
  1. Thinking like a population geneticist
  2. Genotype frequencies
  3. Genetic drift and effective population size
  4. Population structure and gene flow
  5. Mutation
  6. Fundamentals of natural selection
  7. Further models of natural selection
  8. Molecular evolution
  9. Quantitative trait variation and evolution
  10. The Mendelian basis of quantitative trait variation​

Features of the book include:
  • A narrative style and content targeted at multiple learning styles (experiential, intuitive, mathematical and by-example learners)
  • Interact Boxes that contain interactive simulation exercises designed to illustrate fundamental concepts
  • Math Boxes that contain fully explained mathematical details and derivations
  • Chapter summaries that highlight key concepts
  • A large number of two color figures to illustrate and animate the concepts presented
  • Complete coverage of the fundamentals of coalescence theory
  • End-of-chapter problems (with solutions to some problems available to instructors)
Second Edition errata (last updated Sept 15, 2021):

The CV values in Fig. 9.1 are incorrect. A corrected version of Fig. 9.1 is here: population_genetics_2e_fig_9.1_corrected.pdf

What happened to the simulations web site?
Simulations that demonstrate concepts in the text were formerly available at evolutiongenetics.georgetown.edu. As of July, 2024 my institution no longer supports that web site and it has gone off-line permanently. (The web site was initially developed with the support of a grant from Georgetown's Initiative for Technology Enhanced Learning.) 

An alternative is to use Jupyter notebook versions of the simulations written in Python. These produce the same results graphs, except without a user interface. Simulation parameter values can be set in the code. These Jupyter notebook files are also linked on the text resources web page.

All Jupyter notebooks were checked in November, 2024 and updated if needed. 

To use a simulation:
  • Download the ipynd file to your computer
  • Go to https://jupyter.org/try-jupyter/lab/
  • Under Notebook, click on Python
  • Click on upload files icon (top left, small up arrow icon)
  • Upload the ipynd file saved on your computer
  • To see the code, double-click on the uploaded ipynd file at the left
  • There is a text description of the simulation in the top cell
  • The main event loop is at the very bottom of each notebook. In that cell of code you can change the simulation parameter values
  • Select Run -> Run All Cells
  • Look at the resulting figure at the bottom

Hardy-Weinberg de Finetti simulation:
hamiltonlabpage.weebly.com/files/theme/definetti_plot_v2.ipynb
​​
Drift Mutation Selection simulation:
https://hamiltonlabpage.weebly.com/files/theme/drift_selection_mutation.ipynb

Heterozygosity in a finite population:
https://hamiltonlabpage.weebly.com/files/theme/heterozygosity_finite_pop.ipynb

Fixation indices (F_IS, F_ST, & F_IT) in a finite island model:
https://hamiltonlabpage.weebly.com/files/theme/hier_fixation_indices.ipynb

Fates of neutral and nearly neutral mutations:
https://hamiltonlabpage.weebly.com/files/theme/neutral_nearly_neutral_v3.ipynb

Mullers ratchet:
https://hamiltonlabpage.weebly.com/files/theme/mullers_ratchet.ipynb

Mutation simulations:
https://hamiltonlabpage.weebly.com/files/theme/mutation_sim.ipynb

Nucleotide substitution models:
​https://hamiltonlabpage.weebly.com/files/theme/nucleotide_substitution_v2.ipynb


First Edition
Errata for first edition​ of Population Genetics. This file was last updated January 04. 2024.
Reviews of the first edition:
CHOICE Reviews Online, November, 2009 
​(http://www.cro2.org/default.aspx?page=reviewdisplay&pid=3497859)

Human Genetics 126:851-852, December, 2009 (http://www.springerlink.com/content/t3n2k612525r802n/?p=92d11fce3a8a431aad1a4773b9132fc6&pi=10).

The Quarterly Review of Biology 85(1):106, March, 2010 (http://www.journals.uchicago.edu/doi/full/10.1086/650254)
Population Genetics 2E cover
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  • Welcome
  • Matthew B Hamilton
  • Research Topics
  • Members of the lab
  • Text Book
  • Photos
  • Downloads